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#cellbiology
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This looks useful (having battled with mitochondria isolation @roylelab in the past)
Job - Alert 
RESEARCH ASSISTANT / PHD STUDENT (ALL GENDERS) - CELL BIOLOGY OF THE VAMPIRE AMOEBAE I
Deadline: 2025-05-13
Location: Germany, Darmstadt, Hessen
Replied in thread
I’m currently looking for a post-doc in the UK, particularly to work on projects that employ in-vitro reconstitution and quantitative #microscopy approaches to study #cellbiology processes (esspecially #membranetraffic) + would be grateful for sign-posting towards openings! 
#academicchatter
Congratulations to the top 3 images from the Node–FocalPlane image competition!
1. "Cell-estial bloom" by Özge Özgüç
2. "Dancing actinotroch" by Allan Carrillo-Baltodano
3. "Who’s active?" by Julia Peloggia de Castro
Where do #proteins go in cells? Next-generation methods map the molecules’ hidden lives! Spatial #proteomics at the lab of Matthias Mann at Max Planck Institute for Biochemistry is helping biologists to uncover how cells work by mapping where proteins operate. 
Very interesting preprint from Jurgen Klingauf and colleagues demonstrating that synaptic vesicle retrieval is clathrin-mediated.
The debate over the mechanism has been going since the 1970s. In recent years, ultra-fast endocytosis has become accepted. In this paper it's argued that if you look at retrieval of cargo, rather than membrane, then it is mainly driven by clathrin.
bioRxiv · A slow and clathrin-dependent mode of compensatory endocytosis in hippocampal boutons at near-physiological temperatureThe mode of presynaptic compensatory endocytosis has been controversial for decades. Recently, an ultrastructural study on synaptic membrane retrieval following synaptic vesicle fusion revealed an ultrafast mechanism of endocytosis in mouse hippocampal synapses at physiological temperature. Using live cell imaging of single-vesicle exo- and endocytosis in mouse hippocampal synapses, combined with accelerated optogenetic acidification of synaptic vesicles, we found that compensatory endocytosis occurs mostly through a slow clathrin-dependent and actin-independent mode at both room and physiological temperatures.
### Competing Interest Statement
The authors have declared no competing interest.
Interested in membrane organization and contact sites?
Join the DGZ Focus Workshop tomorrow on March 25, 12:00 – 13:45!
The workshop was organized by our research group leader Katja Zieske, among others, as part of the German Society for Cell Biology.
Neighborhood dispute among cells: Whoever successfully transmits force wins
Cells constantly compete, eliminating weaker ones to maintain tissue health. Researchers from #MPZPM, #InstitutJacquesMonod and #NielsBohrInstitute discovered a new strategy in mechanical cell competition: the ability to transmit force determines the winner. Their findings challenge classical views on #CellCompetition.
#science #research #cellbiology
Lucas Anger
Cellular condensates/"droplet organelles" is still such a cool subject to learn about
Imagine that, inside the cell, we not only have the "organs of the cell", the organelles like mitochondria, but also mini-organelles that spontaneously come into being from heaps of "trash protein" (IDR: intrinsically disorganized regions)
A video I watched right now showed how one could use light-emitting apparatus to create such condensates, targeted to specific areas within the given cell
Hello #mastodon and thanks to #Unif for creating this space. Here I am, I didn't bring anything back from my past travels, not even my nickname.
My home is #Inserm and more precisely #IPNP where I look for (and sometimes find) the molecular mechanisms common to my three interests #CellBiology #Neuroscience #Metabolism.
Our lab at the Max Planck Institute for Biological Intelligence (Campus Martinsried) is hiring a lab technician. The position can be filled as soon as possible. All details here: https://keeper.mpdl.mpg.de/f/047f7d13e1a54a26b1ae/
KEEPERLab_Technician_Job_Posting_MPIBI_Mayer.pdfShare link for Lab_Technician_Job_Posting_MPIBI_Mayer.pdf.
On this day 5 years ago, I released version 1.0 of neuVid. It takes high-level descriptions of #Neuroscience or #CellBiology videos and renders them with #Blender or VVD Viewer. Here's a montage of how I've used it. Thanks to #HHMIJanelia for support, especially Steve Plaza and Stuart Berg of FlyEM.
GIF
“I would be quite proud to have served on the committee that designed the E. coli genome. There is, however, no way that I would admit to serving on a committee that designed the human genome. Not even a university committee could botch something that badly” David Penny, quoted in Graur et al. (2013).
And while I’m reading Philip Ball’s “How Life Works”
Continued thread
Hey, wait wait wait, hey. Sounds like ME / CFS, long covid, and post viral syndromes?
https://www.youtube.com/watch?v=vzqXeAtDnTA&t=658s
28-year-old with muscle and breathing problems, plus exercise intolerance.
What if the (possibly implacated) pre-problem pathogens (or other pathways)
are affecting mtDNA expression / production in people who later develop ME / CFS and long covid, etc?
Cuz pathogens can (sometimes) fuck with your wiring, right?
.
I am SO not a doctor, it’s not even funny.
Any fellow non-biologist, non-medic, etc untrained people,
take heed:
this is pure gd CONJECTURE!
Not a law, theory, or even hypothesis.
Just untested speculation on my part: a guess.
Probably decades away from any substantive evidence in any direction.
(Pls do not homeopath thyself, unless thou hast tried all relevant evidenced or at least suggested treatments recommended first.
Non-science aside, please do not take this randomer’s musings as solid anything. Thanke.)
A synthetic protein-level neural network in mammalian cells
https://www.science.org/doi/10.1126/science.add8468
Bringing neural networks to life
A synthetic protein-based winner-take-all neural network controls cell fate decisions
https://www.science.org/doi/10.1126/science.adu1327
Chen et al. describe a protein-level synthetic circuit framework that implements a “winner-take-all” neural network capable of classifying the relative abundance of multiple inputs to modify the circuit output. This network replicates various classification circuits by adjusting the relative concentrations of a few components. By connecting this circuit to molecular pathways that regulate apoptosis, the authors demonstrate the promise of this approach for programming cell fate outcomes. This could be extended to design complex neural circuits that augment the computational capacity of cells.
perceptein: a combination of protein and perceptron.
biorxiv:
https://www.biorxiv.org/content/10.1101/2022.07.10.499405v1.full.pdf
https://phys.org/news/2024-12-perceptein-protein-based-artificial-neural.html
#neuralNetworks #biochem #systemsbiology #proteins #cellbiology
#bioengineering #technology
Continued thread
You’re not just a meat mech; you’re also a colony ship!
Omg. Mitochondria are the influencers of the cell.
But yeah, wild idea somehow. “Pushing people past their limits is damaging.”
IDK why we keep having to explain this to people though.
Just let people live and stop demanding ever more efficient productivity, as if “laziness” both exists and is a marker of a “bad” person.
If you harm people, sure, that’s a bad behaviour I would personally like you to avoid and reduce. But you can harm people by ‘efficiently’ choosing to deny meeting people’s needs.
For Day 17 of #ArtAdventCalendar, I'm sharing one of my early #SciArt pieces. Created with code and illustrations of cell organelles.
Tissues across the scales: Figure 9.1 from "Molecular Biology of the Cell", 7th edition (2022).
#CellBiology #molecules #cells
