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#COVID19

76 posts55 participants4 posts today
Public
Anti. 🐘

"· Children and adolescents face a significantly increased risk of Long COVID following reinfections with SARS-CoV-2
· Another study in Behavioral Sciences showed #LongCOVID also affects language proficiency in children.
· A small observational NIH study is recruiting to study if people with Long COVID have persistent SARS-C0V-2 remnants in their bodies."

thesicktimes.org/2025/04/01/re

The Sick Times - Chronicling the Long Covid crisis · Research updates, April 1 - The Sick TimesChildren and adolescents face a significantly increased risk of Long COVID following reinfections with SARS-CoV-2, according to a new National Institutes of Health (NIH) RECOVER preprint shared on MedRxiv. The study assessed 465,000 children and adolescents under 21 years old using electronic healthcare records from the NIH RECOVER study, focusing on those infected in 2022
#research#COVID19
Public
HuffPost [ES]

🌐 ■ El daño colateral de los aranceles de Trump pueden revivir uno de los miedos de la pandemia ■ El plan arancelario del presidente de EEUU tiene previsto disparar los impuestos que tiene que pagar las importaciones de  abeto desde Canadá, una materia clave en la producción de papel higiénico.
huffingtonpost.es/global/el-da

El papel higiénico de un supermercado en España, casi acabado. (Patricia J. Garcinuno)
#global#eeuu#donaldtrump
Public
ahimsa

"The History of ME deserves a late-night spotlight. That’s why we started the #JohnVsJonVsME campaign"

thesicktimes.org/2025/03/31/th

This campaign was inspired by George Monbiot who called the history of mistreatment of people with Myalgic Encephalomyelitis (ME) the “greatest medical scandal of the 21st century”

Note: Most patients in the USA get a diagnosis of ME/CFS, not ME. CDC info here:

cdc.gov/me-cfs/about/index.htm

As Monbiot wrote, ME still has no approved treatments decades after being first recognized. This lack of scientific progress is too often explained as patients unwilling to get better or an illness too complicated to understand. But in reality, an intentional campaign has obstructed scientific breakthroughs and cures and stigmatized the illness. As a result, medical professionals don’t just neglect people with ME but often only offer them harmful treatments like cognitive behavioral therapy or graded exercise therapy. COVID-19 has added millions of new people with ME to the millions already sick, making coverage of this scandal imperative now more than ever.
#MEcfs#MyalgicEncephalomyelitis#ChronicIllness
Public
Nicole Sharp

Simulating a Sneeze

Sneezing and coughing can spread pathogens both through large droplets and through tiny, airborne aerosols. Understanding how the nasal cavity shapes the aerosol cloud a sneeze produces is critical to understanding and predicting how viruses could spread. Toward that end, researchers built a “sneeze simulator” based on the upper respiratory system’s geometry. With their simulator, the team mimicked violent exhalations both with the nostrils open and closed — to see how that changed the shape of the aerosol cloud produced.

The researchers found that closed nostrils produced a cloud that moved away along a 18 degree downward tilt, whereas an open-nostril cloud followed a 30-degree downward slope. That means having the nostrils open reduces the horizontal spread of a cloud while increasing its vertical spread. Depending on the background flow that will affect which parts of a cloud get spread to people nearby. (Image and research credit: N. Catalán et al.; via Physics World)

Green laser light illuminates a turbulent cloud of aerosol particles produced by a sneeze simulator.
#aerosols#biology#coughing
Replied in thread
Public
datum (n=1)

@DenisCOVIDinfoguy they also cite pubmed.ncbi.nlm.nih.gov/358102

which has this absolute adjective of a hypothesis:

SARS-CoV-2 may bind to ACE2 in order to enter the host brainstem cell and change baroreflex sensitivity

because

The integral parts of the brain renin-angiotensin system, as ACE2 enzyme, are highly expressed in the brainstem, which may also be involved in baroreflex sensitivity, playing an important role in HRV.

which would help explain POTS!!

PubMedPotential autonomic nervous system dysfunction in COVID-19 patients detected by heart rate variability is a sign of SARS-CoV-2 neurotropic features - PubMedIncreasing evidence strongly support that the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to the development of COVID-19-associated central nervous system (CNS) manifestations. The presence of SARS-CoV-2 viral protein in the brainstem, which includes cardiovas …
#COVID#COVID19#SARS2
Replied in thread
Public *
datum (n=1)

@DenisCOVIDinfoguy I was just reading this!

nature.com/articles/s41598-024 has tidbits that range from interesting to wow

non-hospitalized individuals who had COVID-19 present a decrease in heart rate variability with a predominance of the sympathetic nervous system; (2) above all, those evaluated early in the first weeks after infection have less parasympathetic modulation; (3) moderate to large effect sizes were found when comparing groups; (4) the time after diagnosis influences positively while age is negatively associated with HRV parameters

and in a bit of detail:

the LF band, which reflects both modulations but with greater sympathetic predominance, showed a significant increase in the evaluated group during the first weeks after infection, with a tendency to decrease over time. In contrast, the HF band, which reflects parasympathetic activity, exhibited a significant reduction in those evaluated early, indicating diminished parasympathetic activity. However, no increase in this variable was observed over time.

which they immediately explain:

This behavior can be attributed to the different recovery dynamics of the sympathetic and parasympathetic nervous systems after stressors like infection. Sympathetic modulation tends to normalize more quickly following the acute stress response, whereas parasympathetic modulation requires more time to recover, especially after inflammatory states. Additionally, COVID-19 induces vagal suppression, which reduces parasympathetic activity and prolongs its recovery period

vagal refers to the vagus nerve folks, stay calm

NatureImpact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group - Scientific ReportsThis study investigated the impact of mild COVID-19 on HRV in groups stratified by time after infection and to compare to a healthy group of the same age without previous virus infection and without need of hospitalization. This is a cross-sectional study. We divided the sample into four groups: control group (CG) (n = 31), group 1 (G1): ≤6 weeks (n = 34), group 2 (G2): 2–6 months (n = 30), group 3 (G3): 7–12 months (n = 35) after infection. For HRV analysis, we used the indices of linear (time and frequency domain) and non-linear analysis. For comparisons between groups, ANOVA one way test or Kruskal–Wallis was used according to the data distribution. The effect size was calculated based on Cohen’s d or η2. Simple and multiple linear regressions were performed to investigate the interaction between clinical outcomes and HRV parameters. A total of 130 individuals were included. Groups G1 and G2 showed less parasympathetic modulation when compared to CG (p < 0.05), while G3 showed an increase in parasympathetic modulation when compared to G1 (p < 0.05). Moderate to large effect sizes were found according to Cohen d or η2. The multiple linear regression models identified age and infection duration as significant predictors for RMSSD (adjusted R2 = 0.227) and SD1 (adjusted R2 = 0.242), while age was significant for SDNN (adjusted R2 = 0.213). BMI, hypertension, and dyslipidemia were non-significant in all models. For HF (n.u.), infection duration was consistently significant, with stress emerging as a predictor in Model 2 (adjusted R2 = 0.143). The recovery time since diagnosis and age influences recovery from HRV, suggesting a transient effect of the disease on the autonomic nervous system.
#COVID19#COVID#heart
Public
Hilda Bastian

Major funding cuts to the vaccine pipeline announced in the US, but important advances for mucosal Covid vaccines globally:

- 10th mucosal vax reaches phase 2 (in Canada)
- Another human challenge trial as prep for mucosal trials started in Singapore
- Trial results, including one for intranasal vax in kids in China

And lots more in my latest next generation Covid vaccine update now online @PLOS

absolutelymaybe.plos.org/2025/

Absolutely Maybe · Mucosal Covid Vaccine Trials Progress; US R&D Funding Cuts (NextGen Update 27) - Absolutely MaybeThis month, there are results from 3 clinical trials of next generation vaccines, including an early safety study of an intranasal vaccine…
#Vaccines#Covid#Covid19
Public
Ms. Opossum graphs COVID data.

UPDATED: #Ontario #SARSCoV2 variants.

Of 128 samples from 3/9 - 3/15:
XEC.*: 28.1% (〰️ 28.9%; ⬇️ 39.1%)
LP.8.1.*: 23.4% (〰️ 24.5%; ⬇️ 26.6%)
MC.10.1.*: 10.9% (⬆️ 5.9%; ⬆️ 4%)
LF.7.*: 7.8% (⬇️ 11.1%; ⬆️ 2.6%)

ratnegative.tumblr.com/ONVaria #COVID19

----------

Of the samples collected in Ontario on these weeks, the prevalence of each of these significant variants/lineages are as follows:

- 3/9 - 3/15 -
• XEC.* (incl. XEC.2, ".5, ".8, ".11.1, ".14, ".16, ".18, ".21): 28.1%
• LP.8.1.* (incl. LP.8.1.1, NY.3, ".7): 23.4%
• MC.10.1.* (incl. MC.10.1.1, ".10.1.6): 10.9%
• KP.3.3.2.* (incl. NP.1): 3.9%
• LF.7.*: (incl. LF.7.7.1, ".7.7.2): 7.8%

- 3/2 - 3/8 -
• XEC.* (incl. XEC.1 - ".3, ".5, ".8, ".10, ".11.*, ".14, ".18, ".21, ".24): 28.9%
• LP.8.1.* (incl. LP.8.1.1, ".8.1.3, NY.1, ".7): 24.5%
• MC.10.1.* (incl. MC.10.1.2, ".10.1.5, ".10.1.6, PA.1): 5.9%
• KP.3.3.2.* (incl. NP.1): 9.1%
• LF.7.*: (incl. LF.7.1.2, ".7.2.1, ".7.7.2, ".7.8): 11.1%

X.X.* in text = X.X & descendants.

X.X.* in graph = all descendants of X.X, except for ones with own segment of week’s bar.

Public
Tom Kindlon

Brain Structural Abnormalities in Patients with #PostCOVID -19 Headache

mdpi.com/2035-8377/17/4/50

Retrospective 30 vs 30 MRI case/control study. "One of our most noteworthy findings is that white matter lesions were identified in 50% of the post- #COVID-19 group, compared to 20% in the control group”

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #CovidBrain @covid19 #COVID19 #COVID #COVID_19 #SARSCoV2 #CovidIsNotOver #auscovid19 @auscovid19

Public
Tom Kindlon

The US administration has proposed many cuts that may affect ME/CFS or #LongCovid research

Image is from latest Science for ME weekly update

Links:

science.org/content/article/sa

scientificamerican.com/article

thesicktimes.org/2025/03/28/up

fiercebiotech.com/research/stu

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#PASC #postcovid #postcovid19 #PostCovidSyndrome #COVIDBrain
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19

USA - The current administration has proposed many cuts to the NIH and other departments. Cuts or closures may affect ME/CFS or Long Covid research. The final decision on some cuts is still pending. Science "Saying ‘pandemic is over,’ NIH starts cutting COVID-19 research" Article | Thread Scientific American "HHS’s Long COVID Office Is Closing. What Will This Mean for Future Research and Treatments?" Article | Thread The Sick Times "UPDATE: RECOVER Long COVID pathobiology grants restored" Article | Thread Fierce Healthcare 'It's just ugly': Federal funding cuts to Columbia University leave chronic fatigue research in limbo Article | Thread
Public
ahimsa

“Wake Up and Smell the C*VID: An evening without Eric Bogosian”: new play takes aim at NYC mask ban and more

thecanary.co/global/world-news

"As New York State’s budget deadline looms, so too does the specter of a proposed mask ban …"

"Wake Up and Smell the C*VID isn’t a typical play—it’s an intervention. A rupture. A refusal.

It refuses the erasure of an ongoing mass disabling event."

Canary · “Wake Up and Smell the C*VID: An evening without Eric Bogosian”: new play takes aim at NYC mask ban and more“Wake Up and Smell the C*VID: An evening without Eric Bogosian”: new play takes aim at NYC mask ban and more from Canary on 31 March 2025
#COVID#COVID19#LongCovid
Public
cremevax👩🏻‍💻🏳️‍🌈​🇨🇦🇺🇦

Via Katelyn Jetelina ("Your Local Epidemiologist"), the CDC's postponed ACIP meeting, which advises the CDC on vaccines, has finally been rescheduled to April 15 and 16th.

I'm happy to see that Moderna's mRNA-1283 #covid #covid19 NextCOVE vaccine is still on the draft meeting agenda. Relatedly I noticed that mRNA-1283's clinical trials records were updated last week to add study sites in Japan. I had been worried that this NextCOVE vaccine was going to disappear off the face of the Earth, but apparently that's not true. Whew.

More generally on the subject of fall availability of covid vaccines in the US, Jetelina seems to remain hopeful. She thinks the big question is if insurance will cover the cost. I recently expressed some pessimism about the availability of mRNA vaccines in the future, but, unlike me, Jetelina really does have insights into the workings of the CDC. So I am revising my vaccine vibe-o-meter to something a bit more positive. :)

Your Local Epidemiologist newsletter: yourlocalepidemiologist.substa
ACIP meeting agenda: cdc.gov/acip/downloads/agendas

Your Local Epidemiologist · Good riddance flu, fall vaccine plan, fluoride, long Covid research back, and yes, measles.By Katelyn Jetelina
Public
cremevax👩🏻‍💻🏳️‍🌈​🇨🇦🇺🇦

The Sick Times is reporting federal funding for NIH RECOVER grants for long #COVID #COVID19 research has been restored. Advocates did a great job lining up bipartisan support, and the result is a reversal on a really deeply short-sighted decision.

I know it blows to be constantly on defense with this MAHA/DOGE crap, but we can win some of these fights.

thesicktimes.org/2025/03/28/up

The Sick Times - Chronicling the Long Covid crisis · UPDATE: RECOVER Long COVID pathobiology grants restored - The Sick TimesLong COVID research grants from the National Institutes of Health’s RECOVER program will be restored following news stories about their abrupt cancellations and advocacy to restore the funding, according to patient representatives in the initiative.
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