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#Lymphocytes

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“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.

“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.

To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”

Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.

T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.

Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).

It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.

To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.

They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.

“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
newatlas.com/medical/regulator

New Atlas · Immune cell discovery: "The potential to be used for almost everything"A new study has overturned traditional thinking about regulatory T cells, which suppress the body’s inflammatory response, and has significant implications for treating a wide range of conditions, from repairing injured muscles to regrowing hair.

Linchpin of human immune system, T-lymphocytes actually come in a number of subpopulations. CD-4 cells are 'helper-inducer T-cells' that support the production of antibodies by B-lymphocytes. CD-8 cells are cytotoxic T-cells that directly kill microorganisms or cancer cells. Memory T cells are long-lived lymphocytes that can respond to foreign antigens encountered before, even over the entire lifetime of an individual. All of these cells are absolutely required to counter infections such as coronaviruses, measles + hundreds of other infectious diseases in particular. This photo is a colorized scanning electron micrograph of a T-lymphocyte. Not golden in real life but absolute gold in terms of our survival as a species. Good time of the year to give thanks. #lymphocytes #immunity