Reparieren statt zerstören - Fortschritt in der Gentherapie
Eine neue Form der Gentherapie soll in Zukunft eine seltene Lungen- und Lebererkrankung heilen können. Fachleute sprechen von einem bahnbrechenden Fortschritt. Das erste Mal wird ein Gen direkt im Körper repariert. Von Veronika Simon.
Very nice presentation on ligandomics-based treatment selection for personalized vaccination approaches. Prof Juliane Waltz summarised the state-of-the-art...with adjuvant application for #peptide or #mrna vaccines in #Oncology being the current field with promising results. #Immunotherapy combinations bring up the questions: when? What target? And so on... Plenty of aspects to explore! Immunotherapy of cancer conference #ITOC11 #immunology #science #health
New knowledge gained during COVID may protect everybody against tick-carried disease. But only because of an unexpected superpower. It's very "Peter Parker".
#biosphere #mRNA #climatechange #climatefight #science #medicine
Please subscribe to our free #newsletter to see more like this!
https://sweetlightning.ghost.io/the-great-covid-tech-tick-exploit/
@paulschoe @locuta Ik las net in de VK dat er staten zijn waar wetten in de maak zijn waarmee het #mRNA-vaccin verboden gaat worden. Ik snap daar niets van
«I vaccini contro il cancro non erano un vero e proprio campo di ricerca prima della pandemia. Non c'era nulla. A parte un'eccezione, praticamente tutti gli studi clinici erano falliti. Con la pandemia, invece, abbiamo dimostrato che i vaccini a base di mRNA erano possibili», dice il dottor Lennard Lee, oncologo del Servizio sanitario nazionale del Regno Unito e direttore medico presso l'Ellison Institute of Technology di Oxford
https://www.wired.com/story/wired-health-lennard-lee-cancer-vaccines/
« Federal support for #mRNA vaccine research in jeopardy after KFF Health News reported that officials at the National Institutes of Health have directed scientists to remove all references to the technology from their grant applications. All such #research is now under direct scrutiny from health secretary and long-time anti-vaccine advocate Robert F. Kennedy Jr.
A senior official at the NIH's National Cancer Institute confirmed that NIH acting Director "sent an email instructing that any grants, contracts, or collaborations involving mRNA #vaccines be reported to Health and Human Services Secretary and the White House." » 
https://arstechnica.com/health/2025/03/federal-funding-for-mrna-vaccine-research-in-jeopardy-under-rfk-jr/
Update. "Scientists Say #NIH Officials Told Them To Scrub #mRNA References on Grants"
https://kffhealthnews.org/news/article/nih-grants-mrna-vaccines-trump-administration-hhs-rfk/
"National Institutes of Health officials have urged scientists to remove all references to mRNA #vaccine technology from their grant applications…NIH acting Director Matthew Memoli sent an email across the NIH instructing that any grants, contracts, or collaborations involving mRNA vaccines be reported up the chain to #HHS Secretary Robert F. Kennedy Jr.’s office and the White House."
"National Institutes of #Health officials have urged scientists to remove all references to #mRNA vaccine #technology from their grant applications... in a move that signaled the agency might abandon a promising field of medical #research...
#Scientists relayed their experiences on the condition of anonymity for fear of professional retaliation by the #Trump administration...
“Kennedy’s war on vaccines has started”"
https://kffhealthnews.org/news/article/nih-grants-mrna-vaccines-trump-administration-hhs-rfk/
I don't know why the #Trump administration has decided that #mRNA research is suddenly "bad" when it has proven so very useful and effective in prevention and treatment of #disease. As Kevin Collins says:
"Scientists have just cured pancreatic #cancer in some patients with personalized mRNA vaccines. Pancreatic cancer. And this Trump administration wants to throw it all away.
They’re throwing away a cure for cancer."
https://bsky.app/profile/kwcollins.bsky.social/post/3lkjy6ns6fs2x
I can’t believe that NIH may consider defunding #mRNA research. It’s a great way to make effective #vaccines and saves lives. If anyone hasn’t seen Vick Krishna’s explanation, it’s “forking” perfect:
The Viral TikTok Explaining mRNA Vaccines With ... Forks! : Short Wave
https://www.npr.org/2021/04/16/988238718/the-viral-tiktok-explaining-mrna-vaccines-with-forks
The party of death, the #GOP, is now trying to ban #mRNA vaccines in #Iowa https://iowacapitaldispatch.com/2025/03/03/bill-banning-mrna-vaccines-in-iowa-passes-subcommittee/ #iapol
Bill banning mRNA vaccines in ...
@Impossible_PhD I remember reading about Pfizer/BioNTech clinical trials for mRNA vaxx PDAC treatment in 2023, shortly after my mom was diagnosed.
This is immensely important and a huge breakthrough.
Extraordinary work by both BioNTech and MSKCC researchers.
https://www.mskcc.org/clinical-updates/custom-mrna-vaccines-pancreatic
#Trump Team Weighs Pulling Funds for Moderna #BirdFlu #Vaccine
Govt moves to review funding for #mRNA #vaccines #Biden had awarded contract in its final days
#US #health ofcls are reevaluating a $590M contract for bird flu shots that the Biden admin awarded to Moderna Inc.
The review is part of a govt push to examine spending on messenger RNA-based vaccines, the technology that powered Moderna’s #Covid vaccine.
#PublicHealth #RFKJr #HHS #Musk #DOGE #idiocracy #USpol
https://www.bloomberg.com/news/articles/2025-02-26/trump-team-weighs-pulling-funding-for-moderna-bird-flu-vaccine
There are a number of panicky Facebook posts, to which I will not link, going around about the "shocking" discovery that #mRNA #vaccines cross the #placental barrier. Which really shouldn't be a surprise to anyone, but #antivaxers gonna #antivax.
Okay, the discovery is real enough. Here's a direct link: https://www.sciencedirect.com/science/article/pii/S2162253125000435 Click the "View PDF" button at the top, just above the journal title, to read the full article. Note that this is a pre-print version, meaning there may be some typos and such, but nothing that's likely to change the results.
The problem is ... well, there's no problem here! #Maternal #immunity, however acquired, is routinely passed on to #fetuses: we're all born with #immune systems primed to deal with whatever #diseases our mothers have encountered, and that's a *good thing*.
Of course antivaxers who freak out about any occurrence of the abbreviation "mRNA," like the same people often freak out about the word "pronoun" or the "cis-" and "trans-" prefixes, think this is somehow evil.
It's not. It means *fewer dead kids*. These people would literally rather kill their children than learn anything that contradicts their ideology.
@hildabast @sciencefeedback The #MAGA cult members in #Texas who believe there are long term *benefits* from the #measles have one thing in common with the people who preferred #ivermectin or injecting bleach to getting the #mRNA #vaccine during the #COVID pandemic, and probably also those in Jim Jones’ Peoples Temple #cult who drank cyanide-laced Kool-Aid in Jonestown, Guyana. They are/were #PoorlyEducated.
#Resist and support high-quality #PublicEducation.
This NBC story on how mRNA vaccines might show promise in addressing pancreatic cancer was so good, our @ScienceDesk shared it twice. And we’re sharing it a third time because vaccines work, and mRNA vaccines are a phenomenal scientific achievement that should be celebrated.
https://www.nbcnews.com/health/cancer/pancreatic-cancer-vaccine-mrna-treatment-trial-rcna192702
Pancreatic cancer is one of the deadliest forms of the disease, with fewer than 13% of people living more than five years after diagnosis. Personalized mRNA vaccines could be a new option in improving outcomes. In a trial published in Nature, 16 patients with operable pancreatic cancer were given personalized mRNA vaccines after their tumors had been removed. These vaccines were designed to teach the patients' immune systems to attack their cancer cells. Half of the people in the study responded to the vaccine, producing T cells that targeted their tumors. While it was a small phase 1 trial and there are many unknown factors, experts consider the results to be encouraging. “If we can see this response stand up in bigger trials, that’s really significant,” Dr. Shubham Pant, a professor of gastrointestinal medical oncology, told NBC News.
