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#monocytes

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PLOS Biology<p><a href="https://fediscience.org/tags/Remyelination" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Remyelination</span></a> in the CNS is influenced by myeloid cells, including resident <a href="https://fediscience.org/tags/microglia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microglia</span></a> &amp; infiltrating <a href="https://fediscience.org/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a>. This study shows that infiltrating monocytes inhibit the efficiency of CNS remyelination <span class="h-card" translate="no"><a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>PLOSBiology</span></a></span> <a href="https://plos.io/3RryCLF" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3RryCLF</span><span class="invisible"></span></a></p>
Daniel Caron<p>Human aging is assoc. with inflammation and intestinal barrier dysfunction. One might assume that barrier permeability would spark increased inflammation. This (and prev.) work suggests the opposite—that <a href="https://genomic.social/tags/inflammaging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>inflammaging</span></a>, driven by <a href="https://genomic.social/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a> and <a href="https://genomic.social/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>macrophages</span></a> appear to *cause* the barrier dysfunction!</p>
Erin<p>Question to anyone familar with <a href="https://mstdn.social/tags/TransHealthcare" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TransHealthcare</span></a> <a href="https://mstdn.social/tags/Hematology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Hematology</span></a> </p><p>Is there a relationship between elevated <a href="https://mstdn.social/tags/WBC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>WBC</span></a> (<a href="https://mstdn.social/tags/neutrophils" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neutrophils</span></a>, <a href="https://mstdn.social/tags/lymphocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>lymphocytes</span></a>, <a href="https://mstdn.social/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a>) &amp; <a href="https://mstdn.social/tags/Platelets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platelets</span></a>, decreased <a href="https://mstdn.social/tags/RBC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RBC</span></a>, <a href="https://mstdn.social/tags/Hemocrit" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Hemocrit</span></a>, <a href="https://mstdn.social/tags/Anemia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Anemia</span></a>, <a href="https://mstdn.social/tags/Hgb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Hgb</span></a>, <a href="https://mstdn.social/tags/mpv" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mpv</span></a> and <a href="https://mstdn.social/tags/HRT" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>HRT</span></a> for male to female <a href="https://mstdn.social/tags/transgender" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>transgender</span></a> individuals with no other evidence of blood disease, infection or <a href="https://mstdn.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a>? </p><p><a href="https://mstdn.social/tags/CTScans" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CTScans</span></a> are clean, <a href="https://mstdn.social/tags/BoneMarrowBiopsy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BoneMarrowBiopsy</span></a> clean. Doc wants to repeat however.</p>
The EMBO Journal<p><a href="https://sciencemastodon.com/tags/Hypoxia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Hypoxia</span></a> activates SREBP2 through Golgi disassembly in bone marrow-derived <a href="https://sciencemastodon.com/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a> for&nbsp;enhanced tumor growth<br>Tsuyoshi Osawa et al show that low-oxygen conditions induce lineage-specific activation of <a href="https://sciencemastodon.com/tags/SREBP2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SREBP2</span></a> via <a href="https://sciencemastodon.com/tags/Golgi" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Golgi</span></a>-ER fusion, promoting lipid biosynthesis, myeloid cell infiltration, and <a href="https://sciencemastodon.com/tags/tumorigenesis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tumorigenesis</span></a><br><a href="https://www.embopress.org/doi/full/10.15252/embj.2023114032" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">embopress.org/doi/full/10.1525</span><span class="invisible">2/embj.2023114032</span></a></p>
Benjamin S-B :verified:<p>Very exciting that this paper is out now in <a href="https://genomic.social/tags/cancercell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancercell</span></a>: <a href="https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00216-7" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">cell.com/cancer-cell/fulltext/</span><span class="invisible">S1535-6108(23)00216-7</span></a></p><p>In brief: we show that in esophageal <a href="https://genomic.social/tags/adenocarcinoma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>adenocarcinoma</span></a> <a href="https://genomic.social/tags/checkpoint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>checkpoint</span></a> <a href="https://genomic.social/tags/therapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>therapy</span></a> success is predicted by an independent combination of mutation burden and the amount of <a href="https://genomic.social/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a> in the tumour pre-treatment (as measured by RNAseq). Very exciting link between <a href="https://genomic.social/tags/myeloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>myeloid</span></a> cells and <a href="https://genomic.social/tags/immune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immune</span></a> response to <a href="https://genomic.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a>!</p>
Dr. Orna Izakson ND, RH(AHG)<p>Second great thread from <span class="h-card"><a href="https://mstdn.science/@jeffgilchrist" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>jeffgilchrist</span></a></span> explaining ways Covid gets around our immune system’s. Here he describes how it shifts monocytes from their protective function to one that leads to more clotting. And, the virus basically grows your nasal cilia like jack and the bean stock (his analogy) to bypass protective mucus.</p><p>Fascinating and gnarly.</p><p><a href="https://mstdn.science/@jeffgilchrist/109654329276913147" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">mstdn.science/@jeffgilchrist/1</span><span class="invisible">09654329276913147</span></a></p><p><a href="https://newsie.social/tags/Covid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Covid</span></a> <a href="https://newsie.social/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID19</span></a> <a href="https://newsie.social/tags/Monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Monocytes</span></a> <a href="https://newsie.social/tags/ImmuneEvasion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ImmuneEvasion</span></a> <a href="https://newsie.social/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidIsNotOver</span></a></p>
MaksiSanctum he/him<p>Great thread by Dr Gilchrist <span class="h-card"><a href="https://mstdn.science/@jeffgilchrist" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>jeffgilchrist</span></a></span></p><p>How COVID actively suppresses and evades your immune system<br>“ how mild and moderate <a href="https://med-mastodon.com/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID</span></a> infection reprograms white <a href="https://med-mastodon.com/tags/blood" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>blood</span></a> cells (<a href="https://med-mastodon.com/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a>) to reduce <a href="https://med-mastodon.com/tags/innate" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>innate</span></a> <a href="https://med-mastodon.com/tags/immune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immune</span></a> functions and how it evades the mucus layer in our <a href="https://med-mastodon.com/tags/nose" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nose</span></a>”</p><p><a href="https://pingthread.com/thread/1612066649934290946" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pingthread.com/thread/16120666</span><span class="invisible">49934290946</span></a></p>
Jeff Gilchrist<p>How COVID actively suppresses and evades your immune system [Part 2]</p><p>Part 2 looks at how mild and moderate <a href="https://mstdn.science/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID</span></a> infection reprograms white <a href="https://mstdn.science/tags/blood" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>blood</span></a> cells (<a href="https://mstdn.science/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a>) to reduce <a href="https://mstdn.science/tags/innate" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>innate</span></a> <a href="https://mstdn.science/tags/immune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immune</span></a> functions and how it evades the mucus layer in our <a href="https://mstdn.science/tags/nose" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nose</span></a> 🧵 1/</p><p>The one page web view is also available here: <a href="https://pingthread.com/thread/1612066649934290946" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pingthread.com/thread/16120666</span><span class="invisible">49934290946</span></a></p>
Jeff Gilchrist<p>How <a href="https://mstdn.science/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID</span></a> actively suppresses and evades your <a href="https://mstdn.science/tags/immune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immune</span></a> system [Part 1]</p><p>This thread highlights multiple methods that the virus uses to help keep <a href="https://mstdn.science/tags/reinfecting" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>reinfecting</span></a> people including <a href="https://mstdn.science/tags/MHC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MHC</span></a>-I and <a href="https://mstdn.science/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>interferon</span></a> <a href="https://mstdn.science/tags/suppression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>suppression</span></a>, <a href="https://mstdn.science/tags/evasion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>evasion</span></a> of Natural Killer (NK) cells, and reprogramming of <a href="https://mstdn.science/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a>. 🧵 1/</p><p>The one page web view is available here: <a href="https://pingthread.com/thread/1611333222419566594" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pingthread.com/thread/16113332</span><span class="invisible">22419566594</span></a></p>
Claire Adams<p>My first <a href="https://critcare.social/tags/toot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>toot</span></a> and a <a href="https://critcare.social/tags/introduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>introduction</span></a> <br>Currently in my 2nd year of a PhD studying <a href="https://critcare.social/tags/immunometabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunometabolism</span></a> in <a href="https://critcare.social/tags/Monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Monocytes</span></a> and <a href="https://critcare.social/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>macrophages</span></a> in <a href="https://critcare.social/tags/Inflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Inflammation</span></a> as a wannabe <a href="https://critcare.social/tags/clinicianscientist" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>clinicianscientist</span></a> Also full-time servant to a mini panther (Oscar) and currently trying to navigate my way around Mastodon! Looking forward to meeting more people here!</p>
haven4books<p><a href="https://weirder.earth/tags/NEISvoid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NEISvoid</span></a></p><p>Move Over NK, T and B-cells. Are Monocytes the Real Problem in ME/CFS?</p><p>🔗: <a href="https://www.healthrising.org/blog/2022/11/13/monocytes-real-problem-chronic-fatigue-syndrome/" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">healthrising.org/blog/2022/11/</span><span class="invisible">13/monocytes-real-problem-chronic-fatigue-syndrome/</span></a></p><p>"Given the strengths of this study – a large, complex study employing ME/CFS patients from ME/CFS experts that used a more effective technique – it has the potential to alter how this disease is viewed immunologically."</p><p><a href="https://weirder.earth/tags/MECFS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MECFS</span></a> <a href="https://weirder.earth/tags/pwME" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>pwME</span></a> <a href="https://weirder.earth/tags/immune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immune</span></a> <a href="https://weirder.earth/tags/LongCOVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCOVID</span></a> <a href="https://weirder.earth/tags/exercise" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>exercise</span></a> <a href="https://weirder.earth/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://weirder.earth/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCells</span></a> <a href="https://weirder.earth/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>macrophages</span></a> <a href="https://weirder.earth/tags/monocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>monocytes</span></a> <a href="https://weirder.earth/tags/inflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>inflammation</span></a> <a href="https://weirder.earth/tags/NKcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NKcells</span></a> <a href="https://weirder.earth/tags/PEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PEM</span></a> <a href="https://weirder.earth/tags/PESE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PESE</span></a> <a href="https://weirder.earth/tags/platelets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>platelets</span></a> <a href="https://weirder.earth/tags/NIH" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NIH</span></a> <a href="https://weirder.earth/tags/medstodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medstodon</span></a> </p><p><span class="h-card"><a href="https://a.gup.pe/u/mecfs" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>mecfs</span></a></span> <span class="h-card"><a href="https://a.gup.pe/u/longcovid" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>longcovid</span></a></span></p>