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#progesterone

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I’m about to write an email to the corresponding author of the #Progesterone study. This is my current draft:

Dear Koen,

in 2024 you and your team registered a study with BMC Pharmacology and Toxicology in which you declare that you will perform a 1 year study on the effects of progesterone and higher Estradiol-levels in the treatment of transgender individuals. Considering that this was now 1.5 years ago, that you had essentially finished recruiting of participants at the time, and that this is a fully pre-registered study, I am somewhat surprised that you still seem to not have published the results.

I am sure that you are aware that many transgender individuals are awaiting these results not least because many endocrinologists even outside VUMC are refusing to prescribe progesterone, pointing to this supposedly soon to be available study. Naturally this is creating avoidable tension and I am aware of several trans women who have expressed the intention of self-medicating progesterone on top of their officially provided HRT regiments.

It is with this background, that I’d like to know what the current status is and when we can expect the final publication.

Best Regards,
Dr. Fiona Weber
Thoughts anyone?

I figure that this is one of those places where dropping my PhD might be useful; I’m a bit uncertain about the ambiguity regarding my own situation: It’s obvious from my website (trivial to find from my email) that I’m a transgender cryptographer, not a medical doctor, but it’s not like I claim to be. It might come across as me implying it in a deceiving manner though, which could be harmful… So I’m not sure if I should just say it directly to avoid that scenario.

#MedicalTransition #HRT #trans #DutchHellcare

Just got a call from the fuckers in Amsterdam (VUMC) whether they need to keep me on their waiting list. I told them that I’m essentially through the entire process (no thanks to them), and should now be put on Radboud’s surgery waiting-list any day now and that they can remove me from theirs, since I prefer to work with psytrans. (Maybe I should have said “because unlike for you, I do have some trust into those people…”)

I did ask them where in the waiting list they are currently and was told that they are now dealing with people who were referred to them in 2020…

I also asked about the
#progesterone study that they should really have published already, but the person who called me claimed to not really know anything about, go figure…

#transition #medicaltransition #DutchHellCare #trans #VUMC

I'm looking for some advice on starting progesterone. I've been on IM estradiol injections for awhile. Does anyone have some info or advice? Any input would help. Hard to find info online that looks reputable or actually has concrete guidance and my doctor won't say anything beyond "it's up to you". No dose or method recommendation so it's my call on all fronts apparently.

pillowfort.social/posts/592980

Saheli, a 'non-steroidal non-hormonal contraceptive pill'. Saheli dosage starts 1 pill per half-week for ... (?), then 1 pill weekly. Basically induce a brief, mini-menopause that stops when you stop the pills. saheliinfo.com/clinical-eviden

Then! ONE-YEAR vaginal ring Annovera. Unlike monthly-ish vaginal rings, (medicines.org.uk/emc/product/6) this thicker vaginal ring holds enough for 13 cycles with one week bleeding breaks, or 12 if you skip periods. Think "buff NuvaRing". annoverahcp.com/

Speaking of intra-uterine system / device options: the UK does several! We are no longer stuck with the larger, higher dose Mirena hIUS. mirena.co.uk/ I want the smaller, lower dose (but shorter duration) Jaydess fsrh.org/Public/Public/Documen or Kyleena. medicines.org.uk/emc/product/7

(You can fit a non-hormonal IUD copper coil as emergency contraception, within 10 days of unprotected sex. Fitting it as regular birth control anytime otherwise is also fine, when not pregnant.) patient.info/sexual-health/lon

Finally, vasectomy. New part is "I found multiple cases where doctors did their own vasectomies". This may be helpful for hesitant cis men and AMAB people to know. Vasectomies are reversible ("easily", according to a medical nerd friend, but obv different people's bodies respond to things in weird, cool ways, so everything depends). baus.org.uk/_userfiles/pages/f

I am not a doctor. Even if I were, I am not YOUR doctor. I do not have access to your medical records.
I'm just infodumping useful info to prevent unwanted pregnancies, minimise unplanned pregnancies, and mitigate risks. cks.nice.org.uk/topics/contrac

PillowfortMxVerda: Contraception in the UK - limited options but improvingHey! Hey you! new contraceptives / birth control options unfamiliar to the UK. Saheli, a 'non-steroidal non-hormonal contraceptive pill'. Cis women and AFAB people in India have been taking it since the 90s but no international or FDA approval / sought. Saheli dosage starts 1 pill per half-week for ... (?), then 1 pill weekly. Basically induce a brief, mini-menopause that stops when you stop the pills.  https://saheliinfo.com/clinical-evidence Then! ONE-YEAR vaginal ring Annovera. Unlike monthly-ish vaginal rings, (https://www.medicines.org.uk/emc/product/6449/smpc) this thicker vaginal ring holds enough for 13 cycles with one week bleeding breaks, or 12 if you skip periods. Think "buff NuvaRing" -- which I'm now trying! Despite migraines of mulitple types including with aura, while I wait for my IUS fitting on April Fools Day. https://www.annoverahcp.com/ Speaking of intra-uterine system / device options: the UK does several! We are no longer stuck with the larger, higher dose Mirena hIUS. https://www.mirena.co.uk/ I want the smaller, lower dose (but shorter duration) Jaydess https://www.fsrh.org/Public/Public/Documents/ceu-product-review-jaydess-apr-14.aspx or Kyleena. https://www.medicines.org.uk/emc/product/769/smpc (You can have a non-hormonal IUD copper coil fitted as emergency contraception, within 10 days of unprotected sex. Fitting it as regular birth control anytime otherwise is also fine, when not pregnant.) https://patient.info/sexual-health/long-acting-reversible-contraceptives-larc/intrauterine-contraceptive-device Finally, vasectomy. New part is "I found multiple cases where doctors did their own vasectomies". This may be helpful for hesitant cis men and AMAB people to know. Vasectomies are reversible ("easily", according to a medical nerd friend, but obv different people's bodies respond to things in weird, cool ways, so everything depends). https://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Vasectomy.pdf I am not a doctor. Even if I were, I am not YOUR doctor. I do not have access to your medical records. I'm just infodumping useful info to prevent unwanted pregnancies, minimise unplanned pregnancies, and mitigate risks. https://cks.nice.org.uk/topics/contraception-sterilization/management/male-sterilization-vasectomy/ With great(er) awareness of contraceptive options comes great(er) compatibility!~ Your partner in demanding better sexual health options for everyone: some randomer online. 😼 yes, my hobby is telling people things exist https://lgbtqia.space/@MxVerda/114015172551262234

DIY / homebrew HRT query on behalf of a trans gal we know, who lives in Sweden :TransHeart: 🇸🇪

How would someone in Sweden, hypothetically, get progesterone (P4) capsules or cream without a prescription, in light of Sweden's restrictive customs?

It goes without saying that this is necessary as Sweden, like the UK and other countries, has incredibly-poor gender-affirming healthcare for trans people :FaceExhaling:

Our current thoughts are:

  • Find an EU-based pharmacy that's willing to sell progesterone cream without prescription, so customs don't check it 🇪🇺
  • Get an EU-based friend to forward them on.
  • Import progesterone API (CAS 57-83-0) and make them yourself 💊

Thoughts?

important news for aussies taking HRT:

as of march 1st, prometrium (#progesterone), estrogel, and estrogel pro will be added to the PBS - this means you'll be able to get public scripts for them, which will be subsidised. see abc.net.au/news/2025-02-08/fed for more.

the addition of prometrium is especially good news because progesterone was previously only available via PBS as a vaginal gel, and only under very specific conditions: pbs.gov.au/medicine/item/12465

ABC News · Federal Labor promises half a billion dollars for women's health, including better access to long-term contraceptivesBy Tom Lowrey

Effective today, I have discontinued progesterone. The side effects and contraindications reached the point where they were outweighing any further benefit I could expect.

Migraines: 4 in the last 3 days.
Sumitriptan is contraindicated for those with arrhythmia.

In case anyone is wondering where the #progesterone study of the #VUMC can be found: Despite their protocol having been accepted over a year ago, they seemingly still haven’t published their results…

Now, the last tests they want to run are supposed to happen 1 year after starting, so I’m not yet calling for torches and pitchforks, it takes a while to actually start testing and you need to write the actual paper, and…

But my patience is very much on borrowed time… If they are not done by the time I have my next endo-appointment, I will assume that the results were that their E-levels are too low and that Prog works in desirable way, going back to DIY, because I’m past the point of not assuming malice with these folks…

If you have questions, the corresponding author is Koen M.A. Dreijerink (k.dreijerink@amsterdamumc.nl).

#hrt #transition #transgender #transfem #HRT #OpenHRT #DIYHRT

BioMed CentralAddition of progesterone to feminizing gender-affirming hormone therapy in transgender individuals for breast development: a randomized controlled trial - BMC Pharmacology and ToxicologyBackground Feminizing gender-affirming hormone therapy (GAHT) for transgender individuals traditionally includes estradiol and androgen deprivation. Research has demonstrated that breast size as a result of GAHT in transgender women is often limited. Therefore, transgender women often choose to undergo breast augmentation surgery. Progesterone is important for breast development in cisgender women during puberty. A potential role for progesterone in breast development in transgender women has not been investigated in a randomized controlled experimental set-up. The primary objective of this study is to explore the effects on breast volume of addition of oral progesterone to GAHT with estradiol in transgender women after vaginoplasty or orchiectomy. Secondary objectives include assessment of safety, satisfaction, mood, sleep and sexual pleasure. Methods This is a non-blinded, non-placebo, randomized controlled trial using a factorial design in adult transgender individuals assigned male sex at birth who have undergone GAHT for at least one year and underwent vaginoplasty or orchiectomy. The study design allows for rapid assessment of potential synergistic effects of various dose combinations of estradiol and progesterone on breast volume change: Ninety participants will be randomized into six groups of 15 subjects each, receiving either the baseline dose of estradiol, the baseline dose of estradiol and progesterone 200 mg daily, the baseline dose of estradiol and progesterone 400 mg daily, twice the baseline dose of estradiol, twice the baseline dose of estradiol and progesterone 200 mg daily or twice the baseline dose of estradiol and progesterone 400 mg daily, all for a duration of 12 months. The main study parameters include changes in breast volume as determined by 3D measurements. Participants will be followed-up with laboratory testing including serum progesterone concentrations as well as surveys for satisfaction, mood, sleep quality and sexual pleasure. Discussion This study will indicate whether progesterone is safe and of additional value with regard to breast volume change in transgender individuals receiving feminizing GAHT. The results of this study will be useful for innovation of feminizing GAHT. Trial registration WHO International Clinical Trials Registry Platform: EUCTR2020-001952-16-NL; date of registration: 12 December 2020 https://trialsearch.who.int/Trial2.aspx?TrialID=EUCTR2020-001952-16-NL .

Turns out I don't actually have a family history of breast cancer and there are reasons my one relative who had got it rather than just not explainable. Thus, I'm going to try progesterone. It can be purchased over the counter in the US (micronized/bioidentical, the stuff you want), just not prescription strength so I have to use more. Going to use the cream since the other way wouldn't be a good idea for me for reasons and I just don't want to do that.

#trans#transfem#HRT