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#COVID19

68 posts49 participants5 posts today

This week's Featured Links post has links to articles about how Starliner’s flight to the space station was far wilder than most of us thought, a growing conservation burial movement, the sprawling 'metroburb' where 'Severance' is filmed, and nine more.

coredump3.blogspot.com/2025/04

#AI, #COVID19, #Environment, #Finance, #Medical, #Movies #TV, #Politics, #Programming, #Science, #Security, #Society, #Space, #Technology

coredump3.blogspot.comFeatured Links - April 7, 2025Links to things I found interesting but didn't want to do a full blog post about. A floor-cleaning robot   Starliner’s flight to the space s...
medRxiv · Dysautonomia in long COVID is prevalent and could explain the frequency of symptomsBackground Long COVID presents with a variety of symptoms. Some of those symptoms could be related to autonomic dysfunction. Our aim is to evaluate the prevalence of autonomic dysfunction in long COVID patients. Methods We conducted a cross-sectional study and included all consecutive patients enrolled in several clinical research studies. We performed the following autonomic dysfunction markers: heart rate variability, heart rate, systolic and diastolic blood pressure changes during NASA lean test, cardiopulmonary exercise testing and a COMPASS-31 scale. We used linear regression to calculate the contribution of each dysautonomia measure on symptom burden as measured by the modified COVID-19 Yorkshire scale. Results We included 100 patients for this study. Our sample had a mean age of 56+/-11 years, included 53% minorities and 32% were women. Dysautonomia as defined by an abnormal COMPASS-31 was seen in 82%; 95% 72-89 while cardiovascular resting dysautonomia as represented by an abnormal heart rate variability was seen in 60%; 95% 48-70 of the population, orthostatic hypotension in 12% and POTS in 10%. In our adjusted analysis, we found that the beta coefficient for the COMPASS-31 score (0.37) was significant on changes in a self-reported long COVID symptom burden. The orthostatic intolerance and gastrointestinal domains of the COMPASS-31 was associated the highest long COVID symptom burden. Conclusion Dysautonomia is common in long COVID patients and contributes to the overall symptoms seen in long COVID. Identifying dysautonomia has important diagnostic and therapeutic implications. ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Trial NA ### Funding Statement Yes ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: All studies were approved by the research ethics committees at the Miami VAHS and NOVA Southeastern University and all participants signed informed consent prior to participation. Miami VA is the IRB of record I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data cannot be shared publicly because it is owned but the Veterans Affairs.

New UK research:

Long-term effects of #SARSCoV2 infection on blood vessels and blood pressure

journals.lww.com/jhypertension

"Persistent vascular dysfunction and BP increase post-COVID-19 underscore the need for further studies on the long-term risk of hypertension & cardiovascular disease”

@longcovid
#LongCovid #PwLC #LC #PASC #postcovid
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver

Sarah's Tasmanian 'career change' sounds like a dream — until you hear her full story
By Hayley Gleeson

What about the people who change their career not to scratch some creative or philanthropic itch or make a truckload of money, but out of necessity — because illness or injury derailed or destroyed their ability to work?

abc.net.au/news/2025-04-07/car

ABC News · When illness forced Sarah out of work, she thought she'd be off for six months. It turned into eight yearsBy Hayley Gleeson

Huh. New #CovidIsAirborne case-controlled study from Ontario in Feb 2021.

#COVID19 outbreak at a residential apartment building in Northern Ontario, Canada

> being on the upper floors (OR: 10.4; 95% CI: 1.63–66.9) and within three adjacent vertical lines (OR: 28.3; 3.57–225) were both significantly associated with being a case of COVID-19, after adjusting for age. An assessment of the building’s ventilation found uncontrolled air leakage between apartment units. Findings from the multiple components of this investigation are suggestive of aerosol transmission between units.

cambridge.org/core/journals/ep

doi.org/10.1017/S0950268824000

H/t @DickZoutman

It's time to start digging in to my mask project!

I need good, solid resources to back up a presentation I'll be giving to the local public. What are the most reliable and ethical doctors, journalists, advocates, research, statistics, or sites that you've seen?

I'll be talking about air quality, advocating environmental justice through citizen science and mutual aid, and my focus is going to be ventilation and masking.

The program is organized by a local group of folks that started putting up air sensors all over town because of toxic chemical leaks from nearby refineries. They got a grant through a university, and they may be able to help me out in getting an air quality sensor so I can test the CO2 in local buildings. I'd also like to be able to pass out some mask samples. I've been trying to find info on other things like sip valves, elastomeric respirator exhaust valve filter adapters, good sites to buy masks and so on.

Since these issues got politicized and the CDC and WHO are increasingly corrupt/hamstrung, finding good info is a fuckin MESS. I could really use some help!

What's been very interesting to me is, the folks who promote masking are usually ALSO right on other issues. Masks are required at the local anarchist book fairs, for example, which to me says a LOT. The people I follow here on Mastodon who are solidly against genocide, fascism, capitalism, and lesser evilism are the SAME people who are solidly for issues like universal healthcare, right to repair, accessibility, direct action, labor organizing, etc etc-- you have a moral consistency that inspires my respect and hope, and I want to learn more from you!

Next post below will be where I list the sources I've collected, updating as I go.

#masks
#respirators
#ventilation
#COVID19
#covidCautious
#birdFlu
#H5N1
#measles
#publicHealth
#airQuality
#environmentalJustice
#mutualAid
#purpleAir
#citizenScience

Here's an animated map showing the spread of the XFJ variant. The first sample was detected in Cote d'Ivoire in late August. After a long pause, a second sample was detected in South Africa in December. Then it appeared in New York in late February and soon began spreading more widely.

Recently classified XFJ is a recombinant of LF.7 and LS.2. LF.7 is descended from FLiRT JN.1.16.1. LF.7 added several Spike mutations: T22N, S31P, K182R, R190S and K444. LS.2 was descended from JN.1.18.5.

Audio credit:
Swarm_Bees_outdoor_stereo by leonseptavaux -- freesound.org/s/573839/ -- License: Attribution 4.0

With the LP.8.1.* variant on the way to dominance in most places, it is time to ponder which variant might drive the next wave.

The leading contenders at this point are LF.7.7.2, LF.7.9, NB.1.8.1, XEC.25.1 XFH and (new) XFJ.

I show them here using a log scale, so you can compare their growth rates vs the most common LP.8.1.* sub-lineage: LP.8.1.1. There are more recent samples available, but the frequency analysis becomes increasingly distorted due to low volumes and patchy coverage.

#COVID19 #LF_7_7_2 #LF_7_9 #NB_1_8_1 #XEC #XFH #XFJ
🧵

Here's the latest variant picture for the United Kingdom, to late-March.

The XEC.* variant remains dominant, but it is generally declining to around 50% frequency.

Growth of the LP.8.1.* variant seemed to accelerate in the recent samples, to around 28%.

#COVID19 #UK #XEC #LP_8_1
🧵

Here's the latest variant picture for Canada to mid-March. Further samples been back-filled from Ontario, for a more complete picture.

The XEC.* variant is still dominant but has declined to 34%.

The LP.8.1.* variant is challenging at around 24%, probably overhauling the JN.1.* + DeFLuQE variants.

There might be some recent rebound in the FLuQE and FLiRT variants, as unfettered variant evolution continues.

#COVID19 #Canada #XEC #LP_8_1
🧵