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#glp

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Carolyn Barber, MD

More wt loss from Zepbound than Wegovy...

In a 72-wk study, high-dose (7.2mg) Wegovy led patients with obesity to lose 19% of their weight (vs 15.6% with the currently approved 2.4mg dose.)

In comparison, @EliLillyandCo 's Zepbound led to 21% weight loss in its pivotal trial.
shorturl.at/wBu5r #press #glp

STAT · High-dose Wegovy leads to substantial weight loss in trial, but falls short of ZepboundA high dose of Novo Nordisk’s obesity drug Wegovy led patients to lose substantial weight in a clinical trial, but still less than what’s been seen with Zepbound.
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Preston Maness ☭

Sorry, #dulaglutide med #trulicity; the more general description of these drugs is #glp1 receptor agonists.

medscape.com/viewarticle/glp-1

Apparently various professional orgs have been kinda all over the map on whether or not to hold such meds pre-op, but now they are coalescing -- still without formal evidence-based guidance, mind you -- around 24-hour liquid diet in preoperative phase, especially for higher doses of the meds for patients on weekly regimens.

Medscape · GLP-1 RAs Safe in the Perioperative Period: New GuidanceBy Diana Swift
#glp#glp1ra#mounjaro
Public
Steven Saus [he/him]

From 29 Aug: Eli Lilly raises price of Zepbound while trumpeting discount on starter vials - Enlarge / An Eli Lilly & Co. Zepbound injection pen arranged in the Brooklyn borough o... arstechnica.com/science/2024/0 #bernie-sanders #drug-prices #eli-lilly #glp-1 #health-insurance #lilly #prescription-drugs #sanders #science #weight-loss-drugs #zepbound

Public
Brittany Trang

For a company that was founded to "defeat Mother Nature," #Google's #healthtech company #Verily's latest pivot is strangely pedestrian.

It's turning its chronic care program Onduo into a new platform called Lightpath that prescribes #GLP-1s & collects wearable data (including from OTC CGMs for non-diabetic patients) with #AI

for @STAT: statnews.com/2024/06/11/google

STAT · Google’s Verily to offer GLP-1 drugs through Lightpath, its retooled chronic care appGoogle's Verily is pivoting, again. Its chronic disease management app Onduo will transition to a new, “evolved” product called Lightpath.
#health#healthcare#ozempic
Public
Chuck Darwin

#Wegovy®, #Zepbound®, and similar medications continue to gain attention for effectively treating #obesity, and now there is discussion—with research underway—about their potential for improving certain #surgical outcomes.

The brand-name medications mentioned above belong to a class called GLP-1 (glucagon-like peptide-1) agonists. #GLP-1s mimic the actions of the GLP-1 hormone, which is secreted in the gut and sends an “I’m full” signal to the brain after you eat.

GLP-1 medications aren’t new. @Ozempic® (generic name: #semaglutide) received approval from the U.S. Food and Drug Administration (FDA) to treat type 2 diabetes in 2017.

After its weight-loss effects were studied, semaglutide (at a higher dose and sold under the name Wegovy) was approved by the FDA as an anti-obesity medication in 2021, and others have since followed.

Most recently, the FDA approved Wegovy for patients with #cardiovascular #disease and obesity or overweight after a study showed that those taking the medication had a lower overall risk of major cardiac events, such as heart attack, stroke, or cardiovascular-related death.

Now, some Yale Medicine surgeons believe, based on their ongoing research, that taking anti-obesity medications before and sometimes after total #joint #replacement and #bariatric #surgery can be beneficial.

“These medications have been transformative, in terms of expanding the pool of people who can safely undergo joint replacement surgery,” says Daniel Wiznia, MD, a Yale Medicine orthopaedic surgeon and co-director of the Avascular Necrosis Program.

“These anti-obesity medications are game-changers; they are changing the way people practice medicine.”

Often, patients who need a total hip or knee replacement must delay surgery until they lose enough weight to meet specific body mass index ( #BMI ) standards.
This is important in protecting the patient’s health.

“Weight increases a patient’s risk of postoperative complications, including wound-healing problems, stroke, heart attack, blood clots, and infection,” he says.

However, having patients take a GLP-1 medication before surgery, as well as improving their diet, has allowed more patients to reach a safe preoperative BMI, Dr. Wiznia says.

yalemedicine.org/news/anti-obe

Yale MedicineHow Anti-Obesity Medications Can Help With SurgeryYale Medicine surgeons explain how the use of anti-obesity medications, such as Wegovy and Zepbound, before and after joint replacements and bariatric surgery may improve outcomes.
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